Zoloft and Xanax treat different mental health conditions. Zoloft (sertraline) is an SSRI antidepressant used for depression, anxiety, OCD, and PTSD, working gradually to balance serotonin levels. Xanax (alprazolam) is a fast-acting benzodiazepine mainly for short-term relief of anxiety and panic attacks by enhancing GABA activity. While Zoloft is taken daily for long-term treatment, ... https://medscott.com/zoloft-and-xanax/