Abstract Chronic pain remains a significant medical challenge with complex underlying mechanisms. and an urgent need for new treatments. Our research built and utilized the iPain single-cell atlas to study chronic pain progression in dorsal root and trigeminal ganglia. We discovered that senescence of a small subset of pain-sensing neurons may be a driver of chronic pain. https://www.parisnaturalfoodes.shop/product-category/fermented-lions-mane-mushroom/